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Under our proposal, a protocol for the confirmatory study would be set out in advance, specifying the hypothesis, the key outcome measures and the plan for statistical analysis. Enough animals should be studied so that a positive statistical test means that the hypothesis is very likely to be correct (see 'The maths of predictive value'). Sample sizes for this crucial experiment would need to go up; we estimate around sixfold. Overall, however, the subsequent savings in both animals and money are likely to be substantial; fewer people would waste resources following up on weak papers. This would get new drugs to market more quickly.

Having access to photos and videos of my kids in the palm of my hand is a great delight to me (and the Oakley Vault bane of oncetolerant friends and relatives subjected to my unscheduled screenings.) Some great accessories include a video cable to connect the output of the video iPod to your tv and a dock with a remote control so you can connect your iPod to most speakers and have a pretty handy and ultraportable audio system.

Also known as deck shoes or topsiders, boat shoes are moccasins with laces, and are characterized by nonmarking rubber soles. Originally designed to be worn on boats, the rubber soles provide the wearer with a strong grip over the wet and slippery surface of boats Valentino Sale or decks. Not just limited to be worn on boats anymore, boat shoes have made a fashionable mark and are now a part of casual and semiformal attire. Men wear them without socks and pair them with cotton trousers or kneelength shorts.

Just before summer approaches, we always run around to get our cute shorts, skirts, sundresses, and bikini out. All you have to do is roll the ribbon around each strap. Choose one or more ribbons to wrap around the straps. The shine of the ribbon looks amazing in the sun, and can make a great footwear for night parties as well. Cut the ribbon strip long enough so that you can wrap it around the strap properly. They add to the bling missing in your outfit. You will get plastic gems, colorful stones, sequin, and so much more in the market. To make an embellished flip flop, buy predrilled gems in your choice of color(s) along with embroidery string. Sew the gems through the string and then glue it over both straps of the flip flop. Purchase huge plastic flowers, such as sunflower, roses, daisies, to glue where both straps meet. Take a piece of contrasting fabric and stick along the straps of your flip flops. If you are interested in a theme, then a blend of purple, orange, pink, and black prints will do the trick. You can paint Valentino Shoes hearts, butterflies, flowers, stripes, stars, and so much more. Don't forget to paint the straps as well as they will add to the excitement and attraction of the footwear.

asked Sep 22 by valentinoleney (140 points)

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